Infectious diseases account for the majority of deaths in developing countries and are among the ten leading causes of mortality in Canada. The emergence of diverse drug resistant pathogens has made finding new antimicrobial therapies both a Canadian and global health priority. The Lewis research group investigates the connection between metabolic adaptation and virulence of human pathogens. The ultimate goal of this research is to develop new diagnostic methods to identify high risk patients and novel antimicrobial therapies to control infections. One of the key challenges my laboratory faces is unraveling the complex host-pathogen metabolic dynamics that occur during infections. To address this challenge, we use state-of-the-art mass spectrometry (MS) and nuclear magnetic resonance (NMR) technology to comprehensively quantify the flow of molecules between pathogens and their hosts. This metabolomics approach is a powerful strategy for connecting metabolic phenomena with specific genes and is essential for understanding the metabolic determinants of virulence.
The Lewis research group specializes in metabolic analysis of human pathogens. Our facilities include two separate biosafety-level two laboratories dedicated to eukaryotic and prokaryotic pathogens, and a state-of-the-art mass spectrometry laboratory.Learn More
The Lewis research group is located in the University of Calgary in Calgary, Alberta, Canada. Calgary is ranked Canada’s sunniest and the world’s cleanest city. Our lab is located within an hour drive of the world famous Banff National Park and Kananaskis Country.Learn More
Our group includes a mix of students, technicians, and visiting scientists with a common interest in infectious diseases and new diagnostic technology.Learn More
The Lewis laboratory specializes in unraveling complex metabolic networks using high resolution mass spectrometry...Continue Reading
Malaria is thought to have killed more people throughout time than any other disease. Today, more than 500 million people...Continue Reading
One in every 25 patients who goes to the hospital will acquire an infection and 8,000 of these people die each year in Canada...Continue Reading