Calgary Metabolomics Research Facility (CMRF)

The CMRF is a $4 million facility designed specifically for investigating the metabolism of infectious diseases. This facility includes an integrated biosafety level 2 microbiology laboratory, engineering space, and mass spectrometry lab to facilitate research and development of new diagnostic devices and analytical strategies. The CMRF’s dedicated staff provide expertise in high throughput metabolomic and proteomic analyses of a wide variety of complex biological samples.

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Analytical Instrumentation

The CMRF houses the following mass spectrometers:

  • Thermo Fisher Orbitrap Fusion™ Lumos™ Tribrid™

  • Thermo Fisher Q Exactive™ HF Hybrid Quadrupole-Orbitrap™

  • Thermo Fisher Q Exactive™ Hybrid Quadrupole-Orbitrap™

  • Thermo Fisher TSQ Quantum Access Max

Each system is coupled to a Thermo Fisher Vanquish UHPLC system for chromatographic separation.

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Engineering Space

The CMRF houses an integrated engineering facility that develops automation tools and fluidics platforms for rapid identification of microbes. These facilities include:

  • Laser cutter

  • 3D Printer

  • Hot roller

  • Opentron automation platform

  • Electronics bench

  • Machining

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These are essential elements of the LRG rapid diagnostics research program and precision infection management initiatives, both which require high throughput scale-up for pre-clinical evaluation. In addition, this key facility provides a venue for LRG members and collaborators from across the research community to access the engineering infrastructure and expertise needed to develop new diagnostic devices and platforms.

The Facility